MLB Opening Day Betting Odds: Red Sox, Yankees, Mets, Cubs, Angels Among Thursday Games

MLB Opening Day Betting Odds have been posted from various sportsbooks in the U.S. Get a jump on the opening lines and odds as we get close to first pitch. There are some big games, featuring Red Sox-Yankees, Mets-Nationals, and Cubs-Brewers. Shohei Ohtani also starts for the Angels, taking on the Houston Astros. Get ready for Opening Day by comparing betting odds across all the major sportsbooks. If you are a new user, be sure to take advantage of the new-user bonuses by clicking through any of the banners below or through the odds table.

MLB Opening Day Betting Odds

Red Sox At Yankees Betting Odds

Opening Day features Red Sox-Yankees, as they waste no time getting a prime game in to open up the year. Boston will start Nathan Eovaldi and the Yankees turn to Gerrit Cole. New York is a slight favorite in this one and there is a modest run total. Strong arms and weather might keep the offenses at bay in this one. Eovaldi had a 3.71 ERA in six starts against Boston last season. Cole had some issues against Boston last year with a 4.91 ERA in four starts, allowing four home runs.

Brewers At Cubs Betting Odds

Another interdivisional rivalry starts us off on Opening Day in the NL Central. Corbin Burnes, your reigning Cy Young winner, squares off against Kyle Hendricks. The Cubs right-hander has had a rough Spring and will need to hope that is behind him. The weather is going to be wet here as well, so be sure to keep an eye on this one. Milwaukee takes a small advantage on the moneyline as they are expected to start off 2022 with a win.

Mets At Nationals Betting Odds

Patrick Corbin makes the start for the Washington Nationals, while New York has Max Scherzer tentatively scheduled, but that could change due to a small hamstring issue. New York went out and spent this offseason adding to their lineup, but the rotation is a big question mark with Jacob deGrom starting the season on the IL. Corbin has struggled dating back to 2020, after a couple of rough years, he will look to try and turn it around.

Pirates At Cardinals Betting Odds

Our first heavy favorite of the day belongs to the St. Louis Cardinals, as they are home to the Pittsburgh Pirates. The Buccos expect to be basement-dwellers in the NL Central this season, so no surprise to see them start as a massive underdog. However, St. Louis might be overrated a bit, so tread lightly as we are early in the year figuring these teams out. 28-year-old JT Brubaker will make the start for Pittsburgh, while Adam Wainwright makes a familiar Opening Day start.

Astros At Angels Betting Odds

This is certainly a game to tune into with Shohei Ohtani on the mound taking on the Astros. Los Angeles added some nice pieces this offseason and they can show the Astros they are going to have company this year. Ohtani on the mound is must-see TV and he is a small favorite on the road in this one. Framber Valdez will make the start for Houston. Valdez is coming off a terrific 2021 season, boasting a 3.14 ERA over 22 games and just a shade under a strikeout per inning rate.

Padres At Diamondbacks Betting Odds

Yu Darvish makes the start for San Diego as they look to start 2022 in a better spot after a disappointing run in 2021. Health played a part and so far it has not been kind with Fernando Tatis Jr. set to miss the beginning part of the season. Darvish will look to limit a pretty limited offense in Arizona, while Madison Bumgarner is more name value than anything at this stage in his career. While Tatis is out, the Padres offense still have a few bats that hit southpaws well.